Schedule Your Vaccine

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MUSC Health offers the Pfizer-BioNTech vaccine and boosters.

You may schedule your or your child's vaccine appointment with MyChart. If you do not have a MyChart account for your child, please call our COVID-19 help line at 843-876-7227 to schedule.

If you do not have access to the internet or are in need of assistance scheduling your vaccine at a MyChart vaccine clinic location, please review our MyChart registration tip sheet (PDF), or call our COVID Support Line at 843-876-7227.

COVID-19 Boosters

Pfizer-BioNTech Bivalent COVID-19 Vaccine Boosters

On August 31, 2022 a new Pfizer-BioNTech COVID-19 bivalent booster received emergency use authorization from the FDA.

The Pfizer-BioNTech bivalent COVID-19 vaccine is made in the same way as Pfizer-BioNTech monovalent COVID-19 vaccine but it also contains an Omicron component to help prevent COVID-19 caused by the Omicron variant of SARS-CoV-2. This vaccine alteration is similar to what is done with the flu vaccine - adjusting to include the more prevalent strands each year to remain effective.

COVID-19 Vaccines

Eligibility for Children

  • Patients must be at least 7.5kg (16.5 lbs) to receive the vaccine. Please be prepared to give the clinician a recent weight of your child
  • For children under the weight of 16.5 lbs, please schedule an appointment with your pediatrician. If you do not have a pediatrician or your pediatrician is not providing the COVID -19 vaccine at this time, please call our COVID-19 scheduling line at 843-876-7227 to speak with a representative

MUSC Health Vaccination Locations

Charleston Division

Vaccines are available downtown at MUSC Health Rutledge Tower Vaccine Clinic - Charleston.

Columbia Division

Visit the MUSC Health Henderson Street Vaccine Clinic for your vaccine. Appointments preferred, but not required.

Florence Division

Visit our local MUSC Health retail pharmacy to receive your COVID-19 vaccines.

Lancaster Division

Visit our local MUSC Health retail pharmacy to receive your COVID-19 vaccines.

How to Schedule Your COVID-19 Vaccine

If you'd like a demonstration on how to schedule your vaccination appointments, video below can walk you through the process. Press the pause button on the video at any time if you need to take notes or stop on a specific point.

We also have the scheduling information in PDF form for you to download. Spanish version (PDF)

Vaccine Safety Verification

At your vaccination appointment, you will be asked to verify health information to make sure it is safe for you to receive a vaccine. Please be mindful of your answers to these statements as you schedule your appointment(s).

  • If you have already received a first dose of a COVID-19 vaccine, your second dose should be the same brand as the 1st. In exceptional situations, in which the vaccine product given for the first dose cannot be determined or is no longer available, any mRNA vaccine my be administered at a minimum or 28 days between doses. At all clinic locations, MUSC Health offers the Pfizer vaccine exclusively. It has been authorized for ages 5 and up. On rare occasions, Moderna vaccines are administered at MUSC Health community vaccine sites (special allocations by DHEC).
  • Please reschedule if you are feeling sick on the day of your vaccination appointment.
  • If you are in isolation as a result of a positive COVID-19 test, you will not be able to be vaccinated until after your quarantine has ended.
  • If you had a severe reaction to the first dose of the COVID-19 vaccine, you should reach out to your primary care provider to discuss the next appropriate plan of action.
  • If you have previously had a severe reaction to any other vaccine, please plan to remain at the administration site for 30 minutes after vaccination for monitoring.


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