Schedule Your Vaccine

COVID-19 booster shot appointments are available

  • Patients who are age 50+ and/or immunocompromised may now schedule their second booster of the Pfizer COVID-19 vaccine. To schedule, log in to your MyChart account (Click "Schedule an Appointment" from the top menu, then click "COVID Vaccine" from the right column) or call 843-876-7227.
  • First and second booster shots can be scheduled for patients age 12 and up.

Pediatric COVID-19 vaccines

  • Those with MyChart access for their children may schedule online now. If you do not have a MyChart account for your child, please call our COVID-19 help line at 843-876-7227 to schedule.
  • Frequently-asked questions about the pediatric COVID-19 vaccine
En español

MyChart Vaccine Clinic Locations:

Unless otherwise indicated, all locations listed below will administer the Pfizer-BioNTech vaccine, which requires two doses.








North Charleston

If you do not have access to the internet or are in need of assistance scheduling your vaccine at a MyChart vaccine clinic location, please review our MyChart registration tip sheet, or call our COVID Support Line at 843-876-7227.

MUSC Health Vaccine Clinic Holiday Hours

MUSC Health vaccine clinics in the following locations will be closed on Monday, May 30, 2022 in observance of Memorial Day:

  • Charleston County
  • Chester County
  • Florence County
  • Marion County
  • Lancaster County
  • Midlands Counties (Columbia, Kershaw, Elgin)

Choose your county to view upcoming community vaccination events

If you'd like a demonstration on how to schedule your vaccination appointments, this video can walk you through the process. Press the pause button on the video at any time if you need to take notes or stop on a specific point.

We also have the scheduling information in PDF form for you to download. Spanish version (PDF)

Vaccine Safety Verification

At your vaccination appointment, you will be asked to verify health information to make sure it is safe for you to receive a vaccine. Please be mindful of your answers to these statements as you schedule your appointment(s).

  • If you have already received a first dose of a COVID-19 vaccine, your second dose should be the same brand as the 1st. In exceptional situations, in which the vaccine product given for the first dose cannot be determined or is no longer available, any mRNA vaccine my be administered at a minimum or 28 days between doses. At all clinic locations, MUSC Health offers the Pfizer vaccine exclusively. It has been authorized for ages 5 and up. On rare occasions, Moderna vaccines are administered at MUSC Health community vaccine sites (special allocations by DHEC).
  • After receiving the COVID-19 monoclonal antibody infusion, you CANNOT be vaccinated within 90 days of the infusion.
  • Please reschedule if you are feeling sick on the day of your vaccination appointment.
  • If you are in isolation as a result of a positive COVID-19 test, you will not be able to be vaccinated until after your quarantine has ended.
  • If you had a severe reaction to the first dose of the COVID-19 vaccine, you should not receive the second dose.
  • If you have previously had a SEVERE reaction to any other vaccine, please plan to remain at the administration site for 30 minutes after vaccination for monitoring.


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