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Course Title Stop Treating Pain Events--Start Treating Disease. A Clinical Paradigm in Sickle Cell Disease
Presented Date 03/19/2026
Expiration Date 03/19/2029
Presenter(s) Laura M. De Castro
This Presenter does not have any relevant Financial Relationships to disclose.
This activity was not supported by an education grant or any in-kind support.

The Medical University of South Carolina designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Description This is an online grand round from the Department of Medicine
Laura M. De Castro, MD, MHSc Professor of Medicine, Clinical Chief Classical Hematology, Division of Classical Hematology, University of Pittsburgh Medical Center
Objectives Describe the key pathophysiologic mechanisms underlying adult sickle cell disease—including hemolysis, vaso-occlusion, endothelial dysfunction, inflammation, and ischemic organ injury—and correlate these processes with clinical manifestations and progressive organ damage; Compare and apply current and emerging disease-modifying therapies for adults with sickle cell disease by selecting mechanism-based treatment strategies tailored to patient phenotype, comorbidities, and risk profile; Identify and interpret early clinical indicators, laboratory biomarkers, and imaging findings associated with disease progression, and implement evidence-based, multidisciplinary interventions to reduce complications and improve long-term outcomes.
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